Two threads run through this page. The current work is on therapeutics — antisense oligonucleotides for a rare chromosomal microduplication. The earlier work is on machine consciousness and transformer interpretability. Both are kept here.
Antisense, rare disease, CYFIP1, and notes from building a biotech.
May 29, 2026
I spent years working on consciousness and machine cognition. Most of the writing on this site reflects that. Then my older daughter was diagnosed with a chromosomal microduplication that does not have a treatment. The pivot was not a strategic decision.
May 25, 2026
Antisense oligonucleotides are the closest thing rare disease has to a programmable therapy. The mental model that helped me move fastest into the field is treating ASO development as a software stack — with the same kinds of trade-offs, the same kinds of debugging, and the same kinds of failure modes.
May 20, 2026
The 15q region gets most of its attention from UBE3A (Angelman, Dup15q) and SHANK3 (Phelan-McDermid). The proximal BP1–BP2 interval, and CYFIP1 inside it, has been left mostly untouched. That gap is not because the biology is uninteresting.
Earlier work on integrated information, transformers, and the question of phenomenal experience in artificial systems.
March 22, 2026
Project AWAKEN-L — the version that can see inside its own brain. From API keyhole to full hidden-state access.
March 15, 2026
A computer scientist's guide to a structural theory of consciousness—no measure theory required.
March 15, 2026
A new theoretical framework suggests that a mind isn't defined by what it's made of, but by whether its parts can close a causal loop in time.
January 20, 2025
How the global workspace model of consciousness might apply to AI architectures.
January 18, 2025
Why the phenomenological gap may be even deeper when the subject is silicon.
January 15, 2025
How superposition in neural networks complicates the search for conscious representations.
January 12, 2025
Why computing integrated information is computationally intractable—and what researchers do instead.
January 8, 2025
Exploring whether subjective experience could arise in non-biological substrates.
January 5, 2025
A preliminary analysis of whether transformer architectures satisfy structural requirements for consciousness under IIT.